Se han identificado mecanismos inmunoinflamatorios tipo 2 altos, bajos y mixtos, en los cuales la inmunoglobulina E es un biomarcador prominente para el asma de inicio temprano y el asma de inicio tardío no alérgico. Los pacientes en quienes se han abordado factores modificables y continúan con episodios graves de asma aún después de la aplicación de dosis altas de corticosteroides se les diagnostica con asma grave esta se asocia con mayor mortalidad y hospitalizaciones, así como con menor calidad de vida y mayores costos de atención médica. El asma es una enfermedad inflamatoria crónica y heterogénea que afecta las vías respiratorias inferiores tanto de niños como de adultos.
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